Article
No association between variant DNA repair genes and prostate cancer risk among men of African descent.
The Prostate - 1 Feb 2010
Lavender Nicole A, Komolafe Oyeyemi O, Benford Marnita, Brock Guy, Moore Jason H, Vancleave Tiva T, States J Christopher, Kittles Rick A, Kidd La Creis R
Abstract excerpt
BACKGROUND: Recent reports hypothesize that multiple variant DNA repair gene interactions influence cancer susceptibility. However, studies identifying high-risk cancer-related genes use single gene approaches that lack the statistical rigor to model higher order interactions. METHODS: To address this issue, we systematically evaluated individual and joint modifying effects of commonly studied polymorphic base...
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