Article
Genetic variants cis-regulating Xrn2 expression contribute to the risk of spontaneous lung tumor.
Oncogene - 18 Feb 2010
Lu Y, Liu P, James M, Vikis H G, Liu H, Wen W, Franklin A, You M
Abstract excerpt
Gene expression variation is an important mechanism underlying susceptibility to complex disease. In comparison with tobacco-related lung carcinogenesis, lung cancer in nonsmokers may involve important and etiologically distinct causal pathways. In this study, we conducted a genome-wide association study on spontaneous lung tumor incidence in inbred mice and identified a major susceptibility locus on mouse...
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