Article
Brain region specific actions of regulator of G protein signaling 4 oppose morphine reward and dependence but promote analgesia.
Biological psychiatry - 15 Apr 2010
Han Ming-Hi, Renthal Willam, Ring Robert H, Rahman Zia, Psifogeorgou Kassi, Howland David, Birnbaum Shari, Young Kathleen, Neve Rachael, Nestler Eric J, Zachariou Venetia
Abstract excerpt
BACKGROUND: Regulator of G protein signaling 4 (RGS4) is one of the smaller members of the RGS family of proteins, which are known to control signaling amplitude and duration via interactions with G protein alpha subunits or other signaling molecules. Earlier evidence suggests dynamic regulation of RGS4 levels in neuronal networks mediating actions of opiates and other drugs of abuse, but the consequences of RGS4...
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