Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evolution of the rat kallikrein gene family: gene conversion leads to functional diversity.

Journal of molecular evolution - 1 Jun 1991

Wines D R, Brady J M, Southard E M, MacDonald R J

Abstract excerpt

Kallikrein-like simple serine proteases are encoded by closely related members of a gene family in several mammalian species. Molecular cloning and genomic Southern blot analysis after conventional and pulsed-field gel electrophoresis indicate that the rat kallikrein gene family comprises 15-20 members, probably closely linked at a single locus. Determination of the nucleotide sequences of the rGK-3, -4, and -6...

Topics

Amino Acid Sequence
Animals
Base Sequence
Biological Evolution
Gene Conversion
Genes
Genetic Variation
Humans
Kallikreins
Mice
Molecular Sequence Data
Multigene Family

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Rats

Rats, Inbred Strains

Sequence Homology, Nucleic Acid

Source

Identifiers

PMID: 1908019
DOI: 10.1007/BF02102650

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1908019-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evolution of the rat kallikrein gene family: gene conversion leads to functional diversity.PMID 1908019Read ↗

The Expanded Human Kallikrein (KLK) Gene Family: Genomic Organisation, Tissue-Specific Expression and Potential FunctionsSemantic proximity Read ↗

Evolution of the Plasma and Tissue Kallikreins, and Their Alternative Splicing IsoformsSemantic proximity Read ↗

The New Human Tissue Kallikrein Gene Family: Structure, Function, and Association to DiseaseSemantic proximity Read ↗

Evolution of kallikrein-related peptidases in mammals and identification of a genetic locus encoding potential regulatory inhibitorsSemantic proximity Read ↗

New Nomenclature for the Human Tissue Kallikrein Gene FamilySemantic proximity Read ↗

A comprehensive nomenclature for serine proteases with homology to tissue kallikreinsSemantic proximity Read ↗

Tissue-specific Expression Patterns and Fine Mapping of the Human Kallikrein (KLK) Locus on Proximal 19q13.4Semantic proximity Read ↗

The New Human Kallikrein Gene Family: Implications in CarcinogenesisSemantic proximity Read ↗

Evolutionary History of Tissue KallikreinsSemantic proximity Read ↗

The kallikrein world: an update on the human tissue kallikreinsSemantic proximity Read ↗

The Expanded Human Kallikrein Gene Family: Locus Characterization and Molecular Cloning of a New Member, KLK-L3 (KLK9)Semantic proximity Read ↗

The New Human Tissue Kallikrein Gene Family: Structure, Function, and Association to Disease*Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.