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Article

Genetic and epigenetic regulation on the transcription of GABRB2: Genotype-dependent hydroxymethylation and methylation alterations in schizophrenia.

Journal of psychiatric research - 1 May 2017

Zong Lu, Zhou Lin, Hou Yu, Zhang Lulu, Jiang Wei, Zhang Wenwei, Wang Lijuan, Luo Xia, Wang Shiqing, Deng Cong, Peng Zhizhen, Li Shufen, Hu Jiming, Zhao Hu, Zhao Cunyou

Abstract excerpt

To improve our understanding of the abnormalities and non-Mendelian inheritance characteristics of schizophrenia, this study examined DNA methylation (5mC) and hydroxymethylation (5hmC) in the schizophrenia-associated GABRB2 gene encoding the type A γ-aminobutyric acid receptor β2 subunit. DNAs from the peripheral white blood cells of 279 schizophrenic patients and 256 controls from the Chinese Han population...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28063323
DOI: 10.1016/j.jpsychires.2016.12.019

Genes

GABRB2

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