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Article

Conservation of the global sex determination gene tra-1 in distantly related nematodes.

Genes & development - 15 May 2004

Pires-daSilva André, Sommer Ralf J

Abstract excerpt

Sex determination has long intrigued evolutionists, geneticists, and developmental biologists in a similar way. Substantial evidence indicates that sex determination evolves rapidly and, therefore, can be used to study how molecular patterning processes evolve. In Caenorhabditis elegans, sex determination relies on a signaling pathway that involves a cascade of negatively acting factors, finally triggering the...

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Identifiers

PMID: 15155582
DOI: 10.1101/gad.293504
PMCID: PMC415644

Genes

TRA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Conservation of the global sex determination gene tra-1 in distantly related nematodes.PMID 15155582Read ↗

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The C. elegans Sex-Determining GLI Protein TRA-1A Is Regulated by Sex-Specific ProteolysisSemantic proximity Read ↗

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Dominant feminizing mutations implicate protein-protein interactions as the main mode of regulation of the nematode sex-determining gene tra-1.Semantic proximity Read ↗

TRA-1/GLI controls development of somatic gonadal precursors in C. elegans.Semantic proximity Read ↗

Isolation of dominant XO-feminizing mutations in Caenorhabditis elegans: new regulatory tra alleles and an X chromosome duplication with implications for primary sex determination.Semantic proximity Read ↗

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