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Article

Characterization of the East Asian variant of aldehyde dehydrogenase-2: bioactivation of nitroglycerin and effects of Alda-1.

The Journal of biological chemistry - 8 Jan 2010

Beretta Matteo, Gorren Antonius C F, Wenzl M Verena, Weis Robert, Russwurm Michael, Koesling Doris, Schmidt Kurt, Mayer Bernd

Abstract excerpt

The East Asian variant of mitochondrial aldehyde dehydrogenase (ALDH2) exhibits significantly reduced dehydrogenase, esterase, and nitroglycerin (GTN) denitrating activities. The small molecule Alda-1 was reported to partly restore low acetaldehyde dehydrogenase activity of this variant. In the present study we compared the wild type enzyme (ALDH2*1) with the Asian variant (ALDH2*2) regarding GTN bioactivation...

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Source

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Identifiers

PMID: 19906643
DOI: 10.1074/jbc.M109.014548
PMCID: PMC2801295

Genes

ALDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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