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Article

Vascular bioactivation of nitroglycerin by aldehyde dehydrogenase-2: reaction intermediates revealed by crystallography and mass spectrometry.

The Journal of biological chemistry - 2 Nov 2012

Lang Barbara S, Gorren Antonius C F, Oberdorfer Gustav, Wenzl M Verena, Furdui Cristina M, Poole Leslie B, Mayer Bernd, Gruber Karl

Abstract excerpt

Aldehyde dehydrogenase-2 (ALDH2) catalyzes the bioactivation of nitroglycerin (glyceryl trinitrate, GTN) in blood vessels, resulting in vasodilation by nitric oxide (NO) or a related species. Because the mechanism of this reaction is still unclear we determined the three-dimensional structures of wild-type (WT) ALDH2 and of a triple mutant of the protein that exhibits low denitration activity (E268Q/C301S/C303S)...

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Identifiers

PMID: 22988236
DOI: 10.1074/jbc.M112.371716
PMCID: PMC3488082

Genes

ALDH2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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