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Article

Aldehyde dehydrogenase 2 plays a role in the bioactivation of nitroglycerin in humans.

Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 2005

Mackenzie Isla S, Maki-Petaja Kaisa M, McEniery Carmel M, Bao Yi Ping, Wallace Sharon M, Cheriyan Joseph, Monteith Sue, Brown Morris J, Wilkinson Ian B

Abstract excerpt

OBJECTIVE: Nitrates are used widely in clinical practice. However, the mechanism underlying the bioactivation of nitrates to release NO remains unclear. Recent animal data suggest that mitochondrial aldehyde dehydrogenase (ALDH2) plays a central role in nitrate bioactivation, but its role in humans is not known. We investigated the role of ALDH2 in the vascular effects of nitroglycerin (NTG) in humans in vivo....

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Source

Identifiers

PMID: 16051882
DOI: 10.1161/01.ATV.0000179599.71086.89

Genes

ALDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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