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Article

A mutant human IgG molecule with only one C1q binding site can activate complement and induce lysis of target cells.

European journal of immunology - 1 Jan 2006

Michaelsen Terje E, Thommesen John E, Ihle Oistein, Gregers Tone F, Sandin Randi H, Brekke Ole Henrik, Sandlie Inger

Abstract excerpt

There are potentially two binding sites for C1q on IgG, one on each C(H)2 domain of the gamma heavy chains, close to the lower hinge region. It is not clear whether the presence and involvement of both the C1q binding sites is necessary to induce the activation signal of human IgG. In order to clarify this issue, we made a hybrid mutant IgG1/IgG3 molecule where the IgG1 half of the molecule was made unable to...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Electrophoresis, Polyacrylamide Gel

Share to Enzyme-Linked Immunosorbent Assay

Share to Immunoblotting

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Source

Identifiers

PMID: 16323243
DOI: 10.1002/eji.200535178

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A mutant human IgG molecule with only one C1q binding site can activate complement and induce lysis of target cells.PMID 16323243Read ↗

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