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Article

Comparative genomics as a tool to reveal functional equivalences between human and mouse dendritic cell subsets.

Immunological reviews - 1 Mar 2010

Crozat Karine, Guiton Rachel, Guilliams Martin, Henri Sandrine, Baranek Thomas, Schwartz-Cornil Isabelle, Malissen Bernard, Dalod Marc

Abstract excerpt

During evolution, vertebrates have developed an adaptive immune system able to cope with a variety of pathogens. Dendritic cells (DCs) are central to this process. DCs integrate information derived from pathogens or endogenous danger signals and convey them to T lymphocytes. Most of the present knowledge on DCs was generated in mice or by using human DCs differentiated in vitro from monocytes. In both species,...

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PMID: 20193019
DOI: 10.1111/j.0105-2896.2009.00868.x

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