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Article

Smad4 deficiency substitutes Cdkn2b but not Cdkn2a downregulation in pancreatic cancer following induction of genetic events in adult mice.

Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] - 1 Mar 2021

Jia Xintong, Sun Bin, Tu Qiu, Qi Huaxin, Li Lin, Liu Xiuyun, Yan Lanzhen, Dai Hongjuan, Kong Qingpeng, Tang Chengwei, Zhao Xudong

Abstract excerpt

BACKGROUND: Minor progress in pancreatic cancer treatment and prognosis implies that more reliable animal models are urgently needed to decipher its molecular mechanisms and preclinical research. We recently reported a genetically engineered adult mouse model where Cdkn2b downregulation was required together with Cdkn2a downregulation to inactivate the Rb pathway. Besides, the role of Smad4, which is mutated more...

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PMID: 33483239
DOI: 10.1016/j.pan.2021.01.004

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