Article
Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk.
Nature genetics - 1 Dec 2009
Raychaudhuri Soumya, Thomson Brian P, Remmers Elaine F, Eyre Stephen, Hinks Anne, Guiducci Candace, Catanese Joseph J, Xie Gang, Stahl Eli A, Chen Robert, Alfredsson Lars, Amos Christopher I, Ardlie Kristin G, Barton Anne, Bowes John, Burtt Noel P, Chang Monica, Coblyn Jonathan, Costenbader Karen H, Criswell Lindsey A, Crusius J Bart A, Cui Jing, De Jager Phillip L, Ding Bo, Emery Paul, Flynn Edward, Harrison Pille, Hocking Lynne J, Huizinga Tom W J, Kastner Daniel L, Ke Xiayi, Kurreeman Fina A S, Lee Annette T, Liu Xiangdong, Li Yonghong, Martin Paul, Morgan Ann W, Padyukov Leonid, Reid David M, Seielstad Mark, Seldin Michael F, Shadick Nancy A, Steer Sophia, Tak Paul P, Thomson Wendy, van der Helm-van Mil Annette H M, van der Horst-Bruinsma Irene E, Weinblatt Michael E, Wilson Anthony G, Wolbink Gert Jan, Wordsworth Paul, Altshuler David, Karlson Elizabeth W, Toes Rene E M, de Vries Niek, Begovich Ann B, Siminovitch Katherine A, Worthington Jane, Klareskog Lars, Gregersen Peter K, Daly Mark J, Plenge Robert M
Abstract excerpt
To discover new rheumatoid arthritis (RA) risk loci, we systematically examined 370 SNPs from 179 independent loci with P < 0.001 in a published meta-analysis of RA genome-wide association studies (GWAS) of 3,393 cases and 12,462 controls. We used Gene Relationships Across Implicated Loci (GRAIL), a computational method that applies statistical text mining to PubMed abstracts, to score these 179 loci for...
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