Article
Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production.
Nature immunology - 1 Dec 2009
Randall Katrina L, Lambe Teresa, Johnson Andy L, Johnson Andy, Treanor Bebhinn, Kucharska Edyta, Domaschenz Heather, Whittle Belinda, Tze Lina E, Enders Anselm, Crockford Tanya L, Bouriez-Jones Tiphaine, Alston Duncan, Cyster Jason G, Lenardo Michael J, Mackay Fabienne, Deenick Elissa K, Tangye Stuart G, Chan Tyani D, Camidge Tahra, Brink Robert, Vinuesa Carola G, Batista Facundo D, Cornall Richard J, Goodnow Christopher C
Abstract excerpt
To identify genes and mechanisms involved in humoral immunity, we did a mouse genetic screen for mutations that do not affect the first wave of antibody to immunization but disrupt response maturation and persistence. The first two mutants identified had loss-of-function mutations in the gene encoding a previously obscure member of a family of Rho-Rac GTP-exchange factors, DOCK8. DOCK8-mutant B cells were unable...
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