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Article

DOCK8 gene mutation alters cell subsets, BCR signaling, and cell metabolism in B cells.

Cell death & disease - 1 Dec 2024

Gu Heng, Xie Miaomiao, Zhao Siyu, Luo Xi, Huang Yanmei, Yang Lu, Guan Fei, Lei Jiahui, Liu Chaohong

Abstract excerpt

DOCK8 deficiency has been shown to affect the migration, function, and survival of immune cells in innate and adaptive immune responses. The immunological mechanisms underlying autosomal recessive (AR) hyper-IgE syndrome (AR-HIES) caused by DOCK8 mutations remain unclear, leading to a lack of specific therapeutic options. In this study, we used CRISPR/Cas9 technology to develop a mouse model with a specific DOCK8...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39616183
DOI: 10.1038/s41419-024-07180-w
PMCID: PMC11608328

Genes

DOCK8
BCR
AR
GC

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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