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Article

Fetal and postnatal lung defects reveal a novel and required role for Fgf8 in lung development.

Developmental biology - 1 Nov 2010

Yu Shibin, Poe Bryan, Schwarz Margaret, Elliot Sarah A, Albertine Kurt H, Fenton Stephen, Garg Vidu, Moon Anne M

Abstract excerpt

The fibroblast growth factor, FGF8, has been shown to be essential for vertebrate cardiovascular, craniofacial, brain and limb development. Here we report that Fgf8 function is required for normal progression through the late fetal stages of lung development that culminate in alveolar formation. Budding, lobation and branching morphogenesis are unaffected in early stage Fgf8 hypomorphic and conditional mutant...

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Identifiers

PMID: 20727874
DOI: 10.1016/j.ydbio.2010.08.013
PMCID: PMC5133699

Genes

FGF8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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