Article
Memoirs of an insult: sperm as a possible source of transgenerational epimutations and genetic instability.
Molecular human reproduction - 1 Jan 2010
de Boer P, Ramos L, de Vries M, Gochhait S
Abstract excerpt
Male transgenerational epigenetic effects have been discovered in the discipline of mouse radiation genetics, using genetic and non-genetic readouts. The mechanism to explain the origin of the transmission of epigenetic and genetic instability is still unknown. In a search for a hypothesis that could satisfy the data, we propose that regulation of chromosome structure in the germline, by the occupancy of...
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