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Article

Modulation of human placental P-glycoprotein expression and activity by MDR1 gene polymorphisms.

Biochemical pharmacology - 15 Mar 2010

Hemauer Sarah J, Nanovskaya Tatiana N, Abdel-Rahman Sherif Z, Patrikeeva Svetlana L, Hankins Gary D V, Ahmed Mahmoud S

Abstract excerpt

The ABC transporter P-glycoprotein is a product of the MDR1 gene and its function in human placenta is to extrude xenobiotics from the tissue thus decreasing fetal exposure. The goal of this investigation was to examine the effect of three polymorphisms in the MDR1 gene on the expression and activity of placental P-gp. In 199 term placentas examined, the C1236T variant was associated with 11% lower P-gp protein...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19896927
DOI: 10.1016/j.bcp.2009.10.026
PMCID: PMC2812613

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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