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Article

Genetic Polymorphisms of the Human<i>MDR1</i>Drug Transporter

22 Jan 2003

Abstract excerpt

P-glycoprotein is an ATP-dependent efflux pump that contributes to the protection of the body from environmental toxins. It transports a huge variety of structurally diverse compounds. P-glycoprotein is involved in limiting absorption of xenobiotics from the gut lumen, in protection of sensitive tissues (brain, fetus, testis), and in biliary and urinary excretion of its substrates. P-glycoprotein can be inhibited...

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PMID: 12359865
DOI: 10.1146/annurev.pharmtox.43.100901.140233

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