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Article

Neuraminidase mutations conferring resistance to laninamivir lead to faster drug binding and dissociation.

Antiviral research - 1 Feb 2015

McKimm-Breschkin Jennifer L, Barrett Susan

Abstract excerpt

The neuraminidase (NA) inhibitors oseltamivir and zanamivir are administered twice daily for 5days for treatment of influenza. Laninamivir is a 7-methoxy derivative of zanamivir, but a single dose is effective when taken as the laninamivir octanoate prodrug. We show here in IC50 kinetics assays a...

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Identifiers

PMID: 25499124
DOI: 10.1016/j.antiviral.2014.12.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25499124-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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