Article
On the way to targeted therapy of mast cell neoplasms: identification of molecular targets in neoplastic mast cells and evaluation of arising treatment concepts.
European journal of clinical investigation - 1 Aug 2004
Valent P, Ghannadan M, Akin C, Krauth M-T, Selzer E, Mayerhofer M, Sperr W R, Arock M, Samorapoompichit P, Horny H-P, Metcalfe D D
Abstract excerpt
Several emerging treatment concepts for myeloid neoplasms are based on novel drugs targeting cell surface antigens, signalling pathways, or critical effector molecules. Systemic mastocytosis is a haematopoietic neoplasm that behaves as an indolent myeloproliferative disease in most patients, but can also present as aggressive disease or even as an acute leukaemia. In patients with aggressive disease or mast cell...
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