Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional variants of the P2RX7 gene, aseptic osteolysis, and revision of the total hip arthroplasty: a preliminary study.

Human immunology - 1 Feb 2010

Mrazek F, Gallo J, Stahelova A, Petrek M

Abstract excerpt

Periprosthetic osteolysis (OL) is a major long-term complication of the total hip arthroplasty (THA), which can result in aseptic loosening and revision surgery. Purinergic receptor P2X, ligand-gated ion channel 7 (P2RX7) is an important regulator of inflammation and bone turnover. We were therefore interested in whether functional variants of the P2RX7 gene may be associated with OL and risk of THA failure. A...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arthroplasty, Replacement, Hip
Share to Case-Control Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Osteolysis

Share to Polymerase Chain Reaction

Share to Postoperative Complications

Share to Receptors, Purinergic P2

Share to Receptors, Purinergic P2X7

Share to Reoperation

Source

Identifiers

PMID: 19891999
DOI: 10.1016/j.humimm.2009.10.013

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional variants of the P2RX7 gene, aseptic osteolysis, and revision of the total hip arthroplasty: a preliminary study.PMID 19891999Read ↗

Genetic susceptibility to aseptic loosening following total hip arthroplasty: a systematic review.Semantic proximity Read ↗

Genetic susceptibility to hip arthroplasty failure--association with the RANK/OPG pathway.Semantic proximity Read ↗

Genetic susceptibility to aseptic loosening following total hip and knee arthroplasty: a systematic review of candidate-gene and genome-wide association studies.Semantic proximity Read ↗

Genetic susceptibility to total hip arthroplasty failure: a preliminary study on the influence of matrix metalloproteinase 1, interleukin 6 polymorphisms and vitamin D receptor.Semantic proximity Read ↗

The Genetic Variations Associated With Time to Aseptic Loosening After Total Joint Arthroplasty.Semantic proximity Read ↗

Corneal wound malapposition after penetrating keratoplasty: an optical coherence tomography studySemantic proximity Read ↗

Aseptic Loosening in Total Hip Arthroplasty: Pathophysiology, Biomarkers, and Preventive Treatment StrategiesSemantic proximity Read ↗

The role of hereditary hemochromatosis in aseptic loosening following primary total hip arthroplasty.Semantic proximity Read ↗

The BCL2 -938C>A Promoter Polymorphism Is Associated with Risk for and Time to Aseptic Loosening of Total Hip Arthroplasty.Semantic proximity Read ↗

BCL2-938C>A and CALCA-1786T>C polymorphisms in aseptic loosened total hip arthroplasty.Semantic proximity Read ↗

Genetic susceptibility to total hip arthroplasty failure: a case-control study on the influence of MMP 1 gene polymorphism.Semantic proximity Read ↗

Variation in the TNF gene promoter and risk of osteolysis after total hip arthroplasty.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.