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Article

The role of hereditary hemochromatosis in aseptic loosening following primary total hip arthroplasty.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society - 1 May 2005

Lunn J V, Gallagher P M, Hegarty S, Kaliszer M, Crowe J, Murray P, Bouchier-Hayes D

Abstract excerpt

Hereditary hemochromatosis (HH) results in increased iron absorption and subsequent deposition in tissue. This condition occurs predominantly in individuals of Northern European and Celtic origin with Ireland having one of the highest allele frequencies in the world. This study examines the hypothesis that homozygosity for either the C282Y or H63D mutations in the HFE gene may be associated with aseptic loosening...

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Source

Identifiers

PMID: 15885473
DOI: 10.1016/j.orthres.2004.11.004

Genes

HFE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The role of hereditary hemochromatosis in aseptic loosening following primary total hip arthroplasty.PMID 15885473Read ↗

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The Genetic Variations Associated With Time to Aseptic Loosening After Total Joint Arthroplasty.Semantic proximity Read ↗

The BCL2 -938C>A Promoter Polymorphism Is Associated with Risk for and Time to Aseptic Loosening of Total Hip Arthroplasty.Semantic proximity Read ↗

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Precocious bilateral hip joint osteoarthritis is a "form-fruste" of the arthropathy of hereditary haemochromatosis.Semantic proximity Read ↗

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Genetic susceptibility of early aseptic loosening after total hip arthroplasty: the influence of TIMP-1 gene polymorphism on Chinese Han population.Semantic proximity Read ↗

Primary osteoarthritis in the ankle joint is associated with finger metacarpophalangeal osteoarthritis and the H63D mutation in the HFE gene: evidence for a hemochromatosis-like polyarticular osteoarthritis phenotype.Semantic proximity Read ↗

Variation in the TNF gene promoter and risk of osteolysis after total hip arthroplasty.Semantic proximity Read ↗

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