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Article

STAT1 is overexpressed in tumors selected for radioresistance and confers protection from radiation in transduced sensitive cells

30 Jan 2004

Abstract excerpt

Nu61, a radiation-resistant human tumor xenograft, was selected from a parental radiosensitive tumor SCC-61 by eight serial cycles of passage in athymic nude mice and in vivo irradiation. Replicate DNA array experiments identified 52 genes differentially expressed in nu61 tumors compared with SCC-61 tumors. Of these, 19 genes were in the IFN-signaling pathway and moreover, 25 of the 52 genes were inducible by IFN...

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Identifiers

PMID: 14755057
DOI: 10.1073/pnas.0308102100

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Source receipt: pubmed, retrieved 7 Sept 2026.

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