Article
Evolution of an aggressive prolactinoma into a growth hormone secreting pituitary tumor coincident with GNAS gene mutation.
The Journal of clinical endocrinology and metabolism - 1 Jan 2010
Lania Andrea G, Ferrero Stefano, Pivonello Rosario, Mantovani Giovanna, Peverelli Erika, Di Sarno Antonella, Beck-Peccoz Paolo, Spada Anna, Colao Annamaria
Abstract excerpt
CONTEXT: Mixed PRL- and GH-secreting pituitary adenomas are relatively common because somatotrophs and lactotrophs share the common somato-mammotroph progenitor lineage. Conversely, the occurrence of a prolactinoma evolving into clinically and biochemically active acromegaly is a rare phenomenon. OBJECTIVE AND RESULTS: We report a patient with a prolactinoma who after 15 yr of disease control by bromocriptine...
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