Article
A mechanism of acquiring temozolomide resistance during transformation of atypical prolactinoma into prolactin-producing pituitary carcinoma: case report.
Neurosurgery - 1 Jun 2011
Murakami Mineko, Mizutani Akiko, Asano Shuichiro, Katakami Hideki, Ozawa Yoshinori, Yamazaki Kazuto, Ishida Yasuo, Takano Koji, Okinaga Hiroko, Matsuno Akira
Abstract excerpt
BACKGROUND AND IMPORTANCE: The case presented here describes the clinical evolution of a pituitary carcinoma from an atypical prolactinoma after temozolomide (TMZ) treatment. The mechanism of acquisition of TMZ resistance was analyzed. CLINICAL PRESENTATION: A 60-year-old woman with atypical prolactinoma had been treated for 7 years with multiple therapies, including dopamine agonists, surgical intervention (5...
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