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Host and Viral Translational Mechanisms during Cricket Paralysis Virus Infection

5 Nov 2009

Abstract excerpt

The dicistrovirus is a positive-strand single-stranded RNA virus that possesses two internal ribosome entry sites (IRES) that direct translation of distinct open reading frames encoding the viral structural and nonstructural proteins. Through an unusual mechanism, the intergenic region (IGR) IRES responsible for viral structural protein expression mimics a tRNA to directly recruit the ribosome and set the...

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PMID: 19889774
DOI: 10.1128/jvi.02006-09

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