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Article

PKR-mediated stress response enhances dengue and Zika virus replication

21 Sept 2023

Abstract excerpt

ABSTRACT The mechanisms by which flaviviruses use non-canonical translation to support their replication in host cells are largely unknown. Here, we investigated how the integrated stress response (ISR), which promotes translational arrest by eIF2ɑ phosphorylation (p-eIF2ɑ), regulates flavivirus replication. During dengue virus (DENV) and Zika virus (ZIKV) infection, eIF2ɑ phosphorylation peaked at 24 hours...

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Identifiers

PMID: 37732809
DOI: 10.1128/mbio.00934-23

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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