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Article

Multiple Viral Protein Genome-Linked Proteins Compensate for Viral Translation in a Positive-Sense Single-Stranded RNA Virus Infection.

Journal of virology - 14 Sept 2022

Warsaba Reid, Stoynov Nikolay, Moon Kyung-Mee, Flibotte Stephane, Foster Leonard, Jan Eric

Abstract excerpt

Viral protein genome-linked (VPg) protein plays an essential role in protein-primed replication of plus-stranded RNA viruses. VPg is covalently linked to the 5' end of the viral RNA genome via a phosphodiester bond typically at a conserved amino acid. Whereas most viruses have a single VPg, some viruses have multiple VPgs that are proposed to have redundant yet undefined roles in viral replication. Here, we use...

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Identifiers

PMID: 35993738
DOI: 10.1128/jvi.00699-22
PMCID: PMC9472611

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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