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Article

SPINK1 N34S is strongly associated with recurrent acute pancreatitis but is not a risk factor for the first or sentinel acute pancreatitis event.

The American journal of gastroenterology - 1 Feb 2010

Aoun Elie, Muddana Venkata, Papachristou Georgios I, Whitcomb David C

Abstract excerpt

OBJECTIVES: Serine protease inhibitor Kazal type 1 (SPINK1) gene mutations have been associated with chronic pancreatitis of different etiologies; however, little is known about their role in the pathogenesis of acute pancreatitis (AP). Our aim was to study the prevalence of the SPINK1 N34S polymorphism in patients with sentinel and recurrent AP (RAP). METHODS: Patients with AP were enrolled, and genetic tests...

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Source

Identifiers

PMID: 19888199
DOI: 10.1038/ajg.2009.630

Genes

SPINK1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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