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Article

Is the SPINK1 variant p.N34S overrepresented in patients with acute pancreatitis?

European journal of gastroenterology & hepatology - 1 Mar 2012

Jøergensen Maiken Thyregod, Brusgaard Klaus, Novovic Srdan, Andersen Anders Møller, Hansen Mark Berner, Gerdes Anne-Marie, de Muckadell Ove Bent Schaffalitzky

Abstract excerpt

OBJECTIVES: Serine Protease Inhibitor Kazal type 1 (SPINK1) protects against premature intracellular activation of trypsinogen and development of acute pancreatitis. Our aim was to determine the prevalence of SPINK1 mutations (a) in unselected patients with first-time acute pancreatitis and (b) i...

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Source

Identifiers

PMID: 22228370
DOI: 10.1097/MEG.0b013e32834ee5e2

Genes

SPINK1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22228370-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

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Is the SPINK1 variant p.N34S overrepresented in patients with acute pancreatitis?PMID 22228370Read ↗

SPINK1 N34S is strongly associated with recurrent acute pancreatitis but is not a risk factor for the first or sentinel acute pancreatitis event.Semantic proximity Read ↗

Serine Protease Inhibitor Kazal Type I (SPINK1) Mutation: A Risk Factor for Early-onset Chronic Pancreatitis?Semantic proximity Read ↗

The N34S mutation of the SPINK1 gene and alcoholic chronic pancreatitis.Semantic proximity Read ↗

Frequency of SPINK1 N34S mutation in acute and recurrent acute pancreatitis.Semantic proximity Read ↗

Mutations in the serine protease inhibitor Kazal Type 1 (SPINK1) gene in Japanese patients with pancreatitis.Semantic proximity Read ↗

Serine protease inhibitor Kazal type 1 mutations and pancreatitis.Semantic proximity Read ↗

Presence of SPINK-1 variant alters the course of chronic pancreatitis.Semantic proximity Read ↗

Pancreatic Secretory Trypsin Inhibitor (SPINK1) Gene Mutation in Patients with Acute Alcohol Pancreatitis (AAP) Compared to Healthy Controls and Heavy Alcohol Users without Pancreatitis.Semantic proximity Read ↗

Investigation of the SPINK1 N34S mutation in Romanian patients with alcoholic chronic pancreatitis. A clinical analysis based on the criteria of the M-ANNHEIM classification.Semantic proximity Read ↗

Meta-analysis of the impact of SPINK1 p.N34S gene variation in Caucasic patients with chronic pancreatitis. An update.Semantic proximity Read ↗

Serine protease inhibitor kazal type 1 mutations and pancreatitis.Semantic proximity Read ↗

Mutations of the serine protease inhibitor, Kazal type 1 gene, in patients with idiopathic chronic pancreatitisSemantic proximity Read ↗

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