Article
Cellular stress created by intermediary metabolite imbalances.
Proceedings of the National Academy of Sciences of the United States of America - 17 Nov 2009
Lee Sang Jun, Trostel Andrei, Le Phuoc, Harinarayanan Rajendran, Fitzgerald Peter C, Adhya Sankar
Abstract excerpt
Small molecules generally activate or inhibit gene transcription as externally added substrates or as internally accumulated end-products, respectively. Rarely has a connection been made that links an intracellular intermediary metabolite as a signal of gene expression. We report that a perturbation in the critical step of a metabolic pathway--the D-galactose amphibolic pathway--changes the dynamics of the...
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