Article
Common and divergent features of galactose-1-phosphate and fructose-1-phosphate toxicity in yeast.
Molecular biology of the cell - 15 Apr 2018
Gibney Patrick A, Schieler Ariel, Chen Jonathan C, Bacha-Hummel Jessie M, Botstein Maxim, Volpe Matthew, Silverman Sanford J, Xu Yifan, Bennett Bryson D, Rabinowitz Joshua D, Botstein David
Abstract excerpt
Metabolic dysregulation leading to sugar-phosphate accumulation is toxic in organisms ranging from bacteria to humans. By comparing two models of sugar-phosphate toxicity in Saccharomyces cerevisiae, we demonstrate that toxicity occurs, at least in part, through multiple, isomer-specific mechanisms, rather than a single general mechanism.
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