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Article

Global changes to HepG2 cell metabolism in response to galactose treatment.

American journal of physiology. Cell physiology - 1 May 2021

Skolik R A, Solocinski J, Konkle M E, Chakraborty N, Menze M A

Abstract excerpt

Tumor cell proliferation requires sufficient metabolic flux through the pentose phosphate pathway to meet the demand for biosynthetic precursors and to increase protection against oxidative stress which in turn requires an upregulation of substrate flow through glycolysis. This metabolic poise is often coupled with a shift in ATP production from mitochondrial OXPHOS to substrate-level phosphorylation. Despite...

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Share to Carcinoma, Hepatocellular
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33439775
DOI: 10.1152/ajpcell.00460.2020
PMCID: PMC8163570

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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