Article
Intracellular galactose-1-phosphate accumulation leads to environmental stress response in yeast model.
Molecular genetics and metabolism - 1 Nov 2005
Slepak Tatiana, Tang Manshu, Addo Freda, Lai Kent
Abstract excerpt
In humans, deficiency of galactose-1-phosphate uridyltransferase (GALT) can lead a metabolic disorder Classic Galactosemia. Although the biochemical abnormalities associated with this disease have been described in detail, few attempts have been made to characterize the pathogenic mechanisms of this disorder at the molecular level. Here we report the use of high-throughput DNA microarray to examine how galactose...
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