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Article

Alpha5beta1 integrin engagement increases large conductance, Ca2+-activated K+ channel current and Ca2+ sensitivity through c-src-mediated channel phosphorylation.

The Journal of biological chemistry - 1 Jan 2010

Yang Yan, Wu Xin, Gui Peichun, Wu Jianbo, Sheng Jian-Zhong, Ling Shizhang, Braun Andrew P, Davis George E, Davis Michael J

Abstract excerpt

Large conductance, calcium-activated K(+) (BK) channels are important regulators of cell excitability and recognized targets of intracellular kinases. BK channel modulation by tyrosine kinases, including focal adhesion kinase and c-src, suggests their potential involvement in integrin signaling. Recently, we found that fibronectin, an endogenous alpha5beta1 integrin ligand, enhances BK channel current through...

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Identifiers

PMID: 19887442
DOI: 10.1074/jbc.M109.033506
PMCID: PMC2804158

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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