Article
Influence of beta2-adrenoceptor gene polymorphisms on beta2-adrenoceptor expression in human lung.
Pulmonary pharmacology & therapeutics - 1 Apr 2010
Kay Linda J, Suvarna S Kim, Scola Anne-Marie, Rostami-Hodjegan Amin, Chess-Williams Russell, Peachell Peter T
Abstract excerpt
BACKGROUND: The aim of the present study was to establish whether polymorphisms, especially those within the promoter region, of the beta(2)-adrenoceptor gene (ADRB2) influence beta(2)-adrenoceptor expression in human lung. METHODS: The density of beta-adrenoceptors in human lung tissue (n=88) was determined by saturation binding using the radioligand, iodinated cyanopindolol. Discrimination of beta(1)- and...
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