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Breast cancer risks in individuals testing negative for a known family mutation in BRCA1 or BRCA2.

Breast cancer research and treatment - 1 Jan 2010

Domchek S M, Gaudet M M, Stopfer J E, Fleischaut M H, Powers J, Kauff N, Offit K, Nathanson K L, Robson M

Abstract excerpt

Genetic testing for BRCA1 and BRCA2 mutations in family members of individuals with known deleterious mutations can distinguish between patients at high risk of disease and those who are not. Some studies have suggested that individuals testing negative for known familial mutations (true negatives), may still have a higher risk of breast cancer (BC) than the general population. We have examined a prospectively...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19885732
DOI: 10.1007/s10549-009-0611-y

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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