Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Family history of cancer and cancer risks in women with BRCA1 or BRCA2 mutations.

Journal of the National Cancer Institute - 15 Dec 2010

Metcalfe Kelly, Lubinski Jan, Lynch Henry T, Ghadirian Parviz, Foulkes William D, Kim-Sing Charmaine, Neuhausen Susan, Tung Nadine, Rosen Barry, Gronwald Jacek, Ainsworth Peter, Sweet Kevin, Eisen Andrea, Sun Ping, Narod Steven A

Abstract excerpt

Women who carry a deleterious mutation in BRCA1 or BRCA2 have high lifetime risks of breast and ovarian cancers. However, the influence of a family history of these cancers on these risks in women with BRCA mutations is unclear. We calculated cancer incidence rates for a multinational cohort comprising 3011 women with BRCA1 or BRCA2 mutations who were followed up for a mean of 3.9 years, during which time 243...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age Factors
Share to BRCA1 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to BRCA2 Protein

Share to Breast Neoplasms

Share to Odds Ratio

Share to Ovarian Neoplasms

Share to Predictive Value of Tests

Share to Risk Assessment

Source

Identifiers

PMID: 21098759
DOI: 10.1093/jnci/djq443

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Family history of cancer and cancer risks in women with BRCA1 or BRCA2 mutations.PMID 21098759Read ↗

Breast cancer risks in women with a family history of breast or ovarian cancer who have tested negative for a BRCA1 or BRCA2 mutation.Semantic proximity Read ↗

Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case Series unselected for family history: a combined analysis of 22 studies.Semantic proximity Read ↗

Family history of breast cancer as a risk factor for ovarian cancer in a prospective study.Semantic proximity Read ↗

The risk of breast cancer in BRCA1 and BRCA2 mutation carriers without a first-degree relative with breast cancer.Semantic proximity Read ↗

Family history of breast cancer and all-cause mortality after breast cancer diagnosis in the Breast Cancer Family Registry.Semantic proximity Read ↗

Effect of BRCA1 and BRCA2 on the association between breast cancer risk and family history.Semantic proximity Read ↗

Familial risks, early-onset breast cancer, and BRCA1 and BRCA2 germline mutations.Semantic proximity Read ↗

Cancer Incidence in First- and Second-Degree Relatives of BRCA1 and BRCA2 Mutation Carriers.Semantic proximity Read ↗

Family history of breast cancer in first-degree relatives and triple-negative breast cancer risk.Semantic proximity Read ↗

BRCA Genes and Related Cancers: A Meta-Analysis from Epidemiological Cohort Studies.Semantic proximity Read ↗

Population-based estimates of the relation between breast cancer risk, tumor subtype, and family history.Semantic proximity Read ↗

Emerging Trends in Family History of Breast Cancer and Associated Risk.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.