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Article

Serotonin transporter promoter polymorphism and dopaminergic sensitivity in alcoholics.

Journal of neural transmission (Vienna, Austria : 1996) - 1 Jan 2010

Budde Henning, Sander Thomas, Wernicke Catrin, Müller Anett, Gallinat Jürgen, Schmidt Lutz G, Smolka Michael N

Abstract excerpt

The central serotonin (5-HT) system plays an important role in the rewarding and addictive properties of alcohol by a direct activation of the mesolimbic dopamine (DA) system. An insertion/deletion (L/S) promoter polymorphism (5-HTTLPR) of the 5-HT transporter (5-HHT) gene (SLC6A4) has been shown to influence transcriptional activity. It is predicted that reduced transynaptic 5-HT neurotransmission in alcoholics...

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PMID: 19885717
DOI: 10.1007/s00702-009-0331-9

Genes

HTT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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