Article
Dopamine transporter genotype modulation of neural responses to smoking cues: confirmation in a new cohort.
Addiction biology - 1 Apr 2011
Franklin Teresa R, Wang Ze, Li Yin, Suh Jesse J, Goldman Marina, Lohoff Falk W, Cruz Jeffrey, Hazan Rebecca, Jens Will, Detre John A, Berrettini Wade, O'Brien Charles P, Childress Anna Rose
Abstract excerpt
Previously we demonstrated profound effects of dopamine transporter (DAT) SLC6A3 genotype on limbic responses to smoking cues (SCs). Probands carrying at least one copy of the 9-repeat allele (9-repeat carriers) had greater neural responses to SCs in the anatomically interconnected rostral ventral striatum/medial orbitofrontal cortex (VS/mOFC), compared with homozygotes for the 10-repeat allele (10/10-repeats)....
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