Maternal age and chromosomally abnormal pregnancies: what we know and what we wish we knew

Abstract excerpt

PURPOSE OF REVIEW: The relationship between increasing maternal age and trisomy has been recognized for over 50 years and is one of the most important etiological factors associated with any human genetic disorder. Specifically, the risk of trisomy in a clinically recognized pregnancy rises from about 2-3% for women in their twenties to an astounding 30% or more for women in their forties. Thus, as women approach...

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