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Article

Methylation Status of Imprinted Genes and Repetitive Elements in Sperm DNA from Infertile Males

1 Jan 2011

Abstract excerpt

Stochastic, environmentally and/or genetically induced disturbances in the genome-wide epigenetic reprogramming processes during male germ-cell development may contribute to male infertility. To test this hypothesis, we have studied the methylation levels of 2 paternally (H19 and GTL2) and 5 maternally methylated (LIT1, MEST, NESPAS, PEG3, and SNRPN) imprinted genes, as well as of ALU and LINE1 repetitive...

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PMID: 21293114
DOI: 10.1159/000323806

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