Article
Serial investigation of PTPN11 mutation in nonhematopoietic tissues in a patient with juvenile myelomonocytic leukemia who was treated with unrelated cord blood transplantation.
International journal of hematology - 1 Dec 2015
Hiramoto Rika, Imamura Toshihiko, Muramatsu Hideki, Wang Xinan, Kanayama Takuyo, Zuiki Masashi, Yoshida Hideki, Moroto Masaharu, Fujiki Atsushi, Chiyonobu Tomohiro, Osone Shinya, Ishida Hiroyuki, Kojima Seiji, Hosoi Hajime
Abstract excerpt
After allogeneic stem-cell transplantation, nonhematopoietic tissues contain donor-derived cells; however, whether cells from malignant hematological disease can also be found in nonhematopoietic tissues is unclear. This report describes a juvenile myelomonocytic leukemia (JMML) case with a typical PTPN11 mutation (p.E76K) at different allele frequencies in the bone marrow mononuclear cells, buccal smear cells,...
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