Article
Juvenile myelomonocytic leukaemia and Noonan syndrome.
Journal of medical genetics - 1 Oct 2014
Strullu Marion, Caye Aurélie, Lachenaud Julie, Cassinat Bruno, Gazal Steven, Fenneteau Odile, Pouvreau Nathalie, Pereira Sabrina, Baumann Clarisse, Contet Audrey, Sirvent Nicolas, Méchinaud Françoise, Guellec Isabelle, Adjaoud Dalila, Paillard Catherine, Alberti Corinne, Zenker Martin, Chomienne Christine, Bertrand Yves, Baruchel André, Verloes Alain, Cavé Hélène
Abstract excerpt
BACKGROUND: Infants with Noonan syndrome (NS) are predisposed to developing juvenile myelomonocytic leukaemia (JMML) or JMML-like myeloproliferative disorders (MPD). Whereas sporadic JMML is known to be aggressive, JMML occurring in patients with NS is often considered as benign and transitory. However, little information is available regarding the occurrence and characteristics of JMML in NS. METHODS AND...
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