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Diagnosis and treatment of juvenile myelomonocytic leukemia

20 Jun 2016

Abstract excerpt

Juvenile myelomonocytic leukemia (JMML) is a rare myelodysplastic/myeloproliferative disorder that occurs during infancy and early childhood; this disorder is characterized by hypersensitivity of the myeloid progenitor cells to granulocyte-macrophage colony-stimulating factor in vitro. JMML usually involves somatic and/or germline mutations in the genes of the RAS pathway, including PTPN11, NRAS, KRAS, NF1, and...

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PMID: 27322988
DOI: 10.1111/ped.13068

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