Article
Comparison of HIV-1 genotypic resistance test interpretation systems in predicting virological outcomes over time.
PloS one - 9 Jul 2010
Frentz Dineke, Boucher Charles A B, Assel Matthias, De Luca Andrea, Fabbiani Massimiliano, Incardona Francesca, Libin Pieter, Manca Nino, Müller Viktor, O Nualláin Breanndán, Paredes Roger, Prosperi Mattia, Quiros-Roldan Eugenia, Ruiz Lidia, Sloot Peter M A, Torti Carlo, Vandamme Anne-Mieke, Van Laethem Kristel, Zazzi Maurizio, van de Vijver David A M C
Abstract excerpt
BACKGROUND: Several decision support systems have been developed to interpret HIV-1 drug resistance genotyping results. This study compares the ability of the most commonly used systems (ANRS, Rega, and Stanford's HIVdb) to predict virological outcome at 12, 24, and 48 weeks. METHODOLOGY/PRINCIPAL FINDINGS: Included were 3763 treatment-change episodes (TCEs) for which a HIV-1 genotype was available at the time of...
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