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Article

Selection of suppressor methionyl-tRNA synthetases: mapping the tRNA anticodon binding site.

Proceedings of the National Academy of Sciences of the United States of America - 1 Jan 1991

Meinnel T, Mechulam Y, Le Corre D, Panvert M, Blanquet S, Fayat G

Abstract excerpt

Accurate aminoacylation of a tRNA by Escherichia coli methionyl-tRNA synthetase (MTS) is specified by the CAU anticodon. A genetic screening procedure was designed to isolate MTS mutants able to aminoacylate a methionine amber tRNA (CUA anticodon). Selected suppressor MTS enzymes all possess one or several mutations in the vicinity of Trp-461, a residue that is the major contributor to the stability of complexes...

Topics

Anticodon
Escherichia coli
Genes, Bacterial
Genetic Variation
Kinetics
Methionine-tRNA Ligase
Mutagenesis, Site-Directed
RNA, Transfer
Suppression, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 1986377
DOI: 10.1073/pnas.88.1.291
PMCID: PMC50796

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1986377-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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