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Topoisomerase IIα‐dependent induction of a persistent DNA damage response in response to transient etoposide exposure

9 Oct 2009

Abstract excerpt

Cytotoxicity of the topoisomerase II (topoII) poison etoposide has been ascribed to the persistent covalent trapping of topoII in DNA cleavage complexes that become lethal as cells replicate their DNA. However, short term etoposide treatment also leads to subsequent cell death, suggesting that the lesions that lead to cytotoxicity arise rapidly and prior to the onset DNA replication. In the present study 1h...

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PMID: 19858003
DOI: 10.1016/j.molonc.2009.09.003

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