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Article

Etoposide-induced DNA damage is increased in p53 mutants: identification of ATR and other genes that influence effects of p53 mutations on Top2-induced cytotoxicity.

Oncotarget - 1 Jan 2022

Menendez Daniel, Anand Jay R, Murphy Carri C, Bell Whitney J, Fu Jiaqi, Slepushkina Nadia, Buehler Eugen, Martin Scott E, Lal-Nag Madhu, Nitiss John L, Resnick Michael A

Abstract excerpt

The functional status of the tumor suppressor p53 is a critical component in determining the sensitivity of cancer cells to many chemotherapeutic agents. DNA topoisomerase II (Top2) plays essential roles in DNA metabolism and is the target of FDA approved chemotherapeutic agents. Topoisomerase targeting drugs convert the enzyme into a DNA damaging agent and p53 influences cellular responses to these agents. We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35178190
DOI: 10.18632/oncotarget.28195
PMCID: PMC8845119

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